Each bottle CREATON® contains 500 mg, 1 gr, 2 gr, 5 gr Creatine Phosphate.
Creatine Phosphate plays a fundamental role in the energetic mechanism of muscle contraction. It acts as a chemical reserve in the myocardium and skeletal muscle and is used for the resynthesis of ATP, whose hydrolysis supplies ready-for-use energy in the actomyosin contractile process. An inadequate supply of energy caused by the slowing down of oxidative metabolism is a key component in the development and progress of myocardial cell damage. A lack of proper creatine phosphate levels acquires particular clinical significance through impairment of the heart’s contractile force and functional recovery capacity. In myocardial damage, in fact, there is a close correlation between the amount of high-energy-level phosphorylated compounds in the cell, cell survival and ability to recover contractile function. The conservation of high-energy-level phosphorylated compounds is thus a primary objective of all procedures designed to limit myocardial damage, and forms the basis of metabolic protection of the heart. Experimental trials on animal and human cardioplegia has illustrated the role of creatine phosphate and its possibility of protecting the myocardium. The cardiprotective action of creatine phosphate is linked to stabilization of the sarcolemma, preservation of the cell pool of adenine nucleotides through inhibition of nucleotide catabolism enzymes. Creatine phosphate can correct states of metabolic stress by positively influencing the energy reserves, resulting in clinical results in the form of better effort tolerance and, in some situation, the correction of altered bathmotropism.
Deficient striated muscle activity. Coadjuvant in the treatment of myocardial disorders, but not a replacement for cardiokinetic management. For addition to cardioplegic solutions as a means of protection in heart surgery.
DOSES AND WAYS OF ADMINISTRATION
500mg vial: 1 vial i.m. once or twice a day as prescribed by the physician. 1 g vial: 1 vial by i.v. infusion over period of 30-45’ once or twice a day as prescribed by the physician. Cardioplegia: 10mM/I creatine phosphate is added to the usual cardioplegic solutions to provide myocardial protection during heart surgery.
CREATON® box contains: 6 vials 500mg each + 6 solvent glass bottles 50ml each 1 g vial + 50ml solvent glass bottle 2 g vial + 50ml solvent glass bottle 5 g vial + 50ml solvent glass bottle
Keep out of reach of children.
Store below 25 degrees C.
Store away from heat and direct light.